This website uses cookies to enhance your browsing experience, improve site performance, and gather analytics. By selecting 'Accept,' you consent to these cookies as described in our Privacy Policy.

HomeBrowseAboutFAQs
Log In
Sign Up
Variceal Bleeding, Cirrhosis

Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding

Sponsored by Korea University

About this trial

Last updated 7 years ago

Study ID

TPSTOT

Status

Completed

Type

Interventional

Phase

Phase 4

Placebo

No

Accepting

18-75 Years
16 to 75 Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 15 years ago

What is this trial about?

This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

What are the participation requirements?

Yes

Inclusion Criteria

- liver cirrhosis

- age between 16 and 75 years

- Patients who have upper GI bleeding symptoms (hematemesis or melena) within 24 hours before enrollment

- Patients whose systolic blood pressure <100 mmHg or pulse rate >100/min at the enrollment

- Patients who were not performed endoscopic or pharmacologic therapy for varices

- Signed informed consent

No

Exclusion Criteria

- Pregnancy

- Positive anti-HIV Ab

- A history of severe side-effects or contraindications to study drugs

- Severe cardiovascular diseases: acute myocardial infarction, A-V block, congestive heart failure, ischemic heart disease, hypertension (systolic blood pressure >170 mmHg or diastolic pressure >100 mmHg)

- Chronic renal failure

- Hepatocellular carcinoma with protal vein thrombosis

- Coexisting malignancy except hepatocellular carcinoma

Locations

Location

Status