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Renal Function Disorder

Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients

Sponsored by Sun Yat-sen University

About this trial

Last updated 10 years ago

Study ID

SYSU-PRGPD-diuretics

Status

Withdrawn

Type

Interventional

Phase

Phase 3

Placebo

No

Accepting

18-75 Years
20 to 70 Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 12 years ago

What is this trial about?

A prospective, randomized, open-label, stratified, controlled clinical trial to evaluate whether long term furosemide therapy (1 year) would preserve urine volume and/or residual renal function (RRF) and improve fluid state in continuous ambulatory peritoneal dialysis (CAPD) patients.

What are the participation requirements?

Yes

Inclusion Criteria

- Willingness to sign an informed consent

- Age:20~70 years, regardless of gender

- All patients received CAPD more than 1 months;

- Urine volume of 500ml/d or more;

- No history of taking furosemide for at least 2 weeks .

No

Exclusion Criteria

- Inability or unwillingness to sign the informed consent

- Inability or unwillingness to meet the scheme demands raised by the investigators

- Current acute infection such as peritonitis ;

- Severe diarrhea or vomiting within the preceding 1 month

- Acute Cardiac failure

- Myocardial infarction within the preceding 6 months;

- Hypertensive encephalopathy or cerebrovascular accident;

- Accident within the preceding 6 months;

- Any condition, such as alcohol or drug abuse, chronic liver disease, malignant disease, or psychiatric disorder;

- Allergy or intolerance to furosemide .

- Current or recent (within 2 weeks) exposure to any other investigational drugs