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Cytomegalovirus Retinitis
+1

A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy

Sponsored by National Institute of Allergy and Infectious Diseases (NIAID)

About this trial

Last updated 17 years ago

Study ID

ACTG 379

Status

Completed

Type

Observational

Placebo

No

Accepting

18-75 Years
13+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

What is this trial about?

The purpose of this study is to see if it is safe to stop maintenance therapy in HIV-positive patients with treated and healed CMV retinitis (eye disease) who have responded well to anti-HIV (antiretroviral) therapy. The current therapies available to treat CMV retinitis are long-term therapies. However, it may be safe to stop long-term anti-CMV therapy in patients with healed CMV retinitis and stable CD4 counts resulting from taking a combination of at least 2 antiretroviral drugs.

What are the participation requirements?

Yes

Inclusion Criteria

- Are HIV-positive.

- Have a CD4 count greater than 100 cells/mm3.

- Have healed CMV retinitis after receiving anti-CMV therapy for at least 8 weeks within 3 months prior to study entry.

- Have taken antiretroviral therapy for at least 8 weeks prior to study entry; combination therapy must include at least 2 of the following: protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), or non-nucleoside reverse transcriptase inhibitors (NNRTIs).

- Have a life expectancy of at least 6 months.

- Are at least 13 years old (need consent if under 18).

No

Exclusion Criteria

- Have any unstable or severe medical conditions that would keep you from completing the study.

- Require chemotherapy or radiation therapy.

- Have a history of certain eye disorders.

Locations

Location

Status