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Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

Sponsored by Colgate Palmolive

About this trial

Last updated a month ago

Study ID

CRO-2025-06-ERO-MS

Status

Active not recruiting

Type

Interventional

Phase

Phase 3

Placebo

No

Accepting

18 to 70 Years
All Sexes

Trial Timing

Ended a month ago

What is this trial about?

The goal of this clinical trial is to learn if a new toothpaste can prevent enamel erosion in healthy adults. Researchers will compare the test toothpaste to a control toothpaste to see if there is a difference in erosion levels. Participants will brush twice a day for two minutes with their assigned toothpaste.

What are the participation requirements?

Inclusion Criteria

* Sign an Informed Consent Form;

* Male or female 18 to 70 years of age, inclusive;

* Be in good general health as determined by the study investigators;

* Available for the eighteen (18) days duration of the study;

* Have normal salivary flow rate (stimulated and unstimulated flow of ≥0.7 ml/min and ≥0.2 ml/min respectively) ascertained from a preliminary saliva examination;

* Have healthy salivary pH (unstimulated saliva pH 6.8-7.8) ascertained from a preliminary saliva test;

* Must be able to accept a well-fitting removable intraoral appliance bearing at least two enamel specimens.

Exclusion Criteria

* Gross oral pathology, chronic disease, and/or history of allergies to any of the test products;

* Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past three months prior to start of the study;

* Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months;

* Obvious signs of dental erosion Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;

* Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics, or medication which alters salivary flow

* Participation in any other oral clinical study for the duration of this study

* Self-reported pregnancy and/or currently breastfeeding;

* Allergies to oral care products, personal care consumer products, and/or their ingredients;

* Medical condition which prohibits not eating/drinking for 4 hours.