This website uses cookies to enhance your browsing experience, improve site performance, and gather analytics. By selecting 'Accept,' you consent to these cookies as described in our Privacy Policy.

Logo

A Bioequivalence Study of Two Different PEG-rhGH Preparations

Sponsored by Changchun GeneScience Pharmaceutical Co., Ltd.

About this trial

Last updated 10 months ago

Study ID

GenSci004-112

Status

Completed

Type

Interventional

Phase

Phase 1

Placebo

No

Accepting

18 to 45 Years
Male

Trial Timing

Ended a year ago

What is this trial about?

The purpose of this study is to investigate whether PEG-rhGH with new preparation is bioequivalent to PEG-rhGH with present preparation.

What are the participation requirements?

Inclusion Criteria

* Healthy male aged ≥18 years old and≤45 years old;

* The Body mass index (BMI): 19-26 kg/m2 (inclusive), and body weight ≥50 kg;

* Normal results of physical examination, vital signs, laboratory tests, 12 lead-ECG, chest X-ray, abdominal ultrasound, or non-clinical significance changes in the assessments above.

Exclusion Criteria

* Subjects with a history of hypersensitivity reactions or clinically significant hypersensitivity reactions to drugs containing; or a history of allergic diseases (including but not limited to asthma, urticaria, etc.), or allergic constitution (such as known allergy to two or more substances)

* Subjects with a clear history of disorders of the central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, metabolic system, etc., or suggest potential diseases, such as abnormal laboratory test results of liver and kidney function (alanine aminotransferase [ALT] or aspartate aminotransferase [AST] exceeding the upper limit of normal, or total bilirubin exceeding the upper limit of normal; Or blood creatinine exceeding the upper limit of normal value); Or other diseases (such as a history of mental illness) deemed unsuitable for participation in the trials by the investigators;

* Subjects with severe infection, severe trauma, or major surgery within 6 months prior to screening;

* Subjects who have received blood transfusions, had blood donors, or lost blood ≥400 mL within 3 months before screening; Or plan to donate blood within 1 month of the end of the trial;

* Subjects who have positive results of human immunodeficiency virus antibodies (HIV-Ab), or hepatitis B surface antigen (HBsAg), or hepatitis C virus antibodies (HCV-Ab), or syphilis specific antibodies (TPPA);

* Subjects who have participated in clinical trials for medication or medical device within 3 months prior to screening;etc.