A Dose-finding Study of JMKX003142 in Treatment of Renal Edema

- Patients who can fully understand the purpose and process of the study and voluntarily sign the ICF;

- Age ≥ 18 years old during screening;

- Diagnosed as renal edema during screening;

- eGFR ≥ 15 mL/min/1.73m2 during screening.

- Patients who are receving the renal replacement therapy during screening or patients who require renal replacement therapy in the short term evaluated by the researchers;

- Patients who are suspected with hypovolemia;

- Patients with the following diseases or symptoms: acute thrombosis, diarrhea, and difficulty urinating;

- Patients who are unable to sense thirst or who have difficulty with fluid intake;

- Patients who have received AVP-V2R blockers within 30 days prior to the screening examination;

- The following laboratory indicators are abnormal: ALT ≥ 1.5 × ULN, AST ≥ 1.5 × ULN, serum sodium>ULN, D-dimer ≥ 2 × ULN;

- Patients who received diuretics or treatments with diuretic effects from Day-2 to randomization;

- During screening, SBP <90mmHg/DBP<60mmHg, SBP>160mmHg/DBP >100mmHg;

- Patients who have a history of allergies to ≥ 3 substances, or are currently in an allergic state;

- Female patients who are breast-feeding or who have a positive pregnancy test result prior to receiving investigational product (IMP);

- Sexually active males or women of childbearing potential (WOCBP) who do not agree to practice birth control or remain abstinent during the trial and for 30 days after the final IMP administration.