This single-center prospective study aims to investigate the electrophysiological
characteristics and functions of the human claustrum by analyzing clinical, imaging, and
electrophysiological data from 14~65-year-old patients with drug-resistant epilepsy.

Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG

Refractory Epilepsy

Consciousness, Loss of

Stereoelectroencephalography (SEEG) is a method for recording electrical activity from
deep brain structures using implanted depth electrodes to provide a three-dimensional
view of neuronal activity.

Direct Electrical Stimulation (DES) is a neurosurgical technique that involves delivering
electrical impulses to specific brain regions through implanted electrodes to map
critical functional areas and to study the connectivity of brain regions.

This study aims to investigate the electrophysiological characteristics and functions of
the human claustrum by analyzing clinical, imaging, and electrophysiological data from
patients aged 14 to 65 implanted intracranial electrodes , with a specific focus on
electrodes targeting the claustrum. This research forms part of a broader initiative to
explore the functions of cortical and subcortical regions based on SEEG.

Direct Electrical Stimulation

Researchers categorized patients' clinical responses as normal, mild, moderate, or severe
based on their subjective clinical response.

Using SEEG-implanted electrodes, the investigators applied electrical stimulation of
varying intensities to the CLA while observing and recording EEG power changes across six
spectral frequency bands during the pre-stimulation, stimulation, and post-stimulation
periods.

EEG Frequency Bands

  -  delta (1-4 Hz)

  -  theta (5-8 Hz)

  -  alpha (9-12 Hz)

  -  beta (13-30 Hz)

  -  low gamma (31-70 Hz)

  -  high gamma (71-150 Hz)

All cortical-evoked responses were averaged by time-locking the recordings to the onset
of each electrical stimulus (zero) off-line, within a time window of -200 to +400 mses,
to quantify the morphology.

The N1 peak, identified as the first negative deflection distinguishable from the
stimulus artifact, was the primary focus due to its clear visibility and reproducibility
across different stimulations.

The root mean square (RMS) value will be calculated for different cortical locations
during time windows that encompass both the N1 peak(early response time time window) and
the baseline.

A paired one-sample t-test will be used to compare the RMS values in the early response
time window across different cortical sites with the RMS values in the baseline.

Professor

The investigators performed direct electrical stimulation of the claustrum in
drug-resistant epilepsy patients underwent SEEG monitoring.The investigators observed the
neural activities before, during, and after stimulation and the claustrum-cortical
network to figure out the role of claustrum in consciousness and its underlying
electrophysiological mechanism.

Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG

About this trial

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Placebo

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