Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability

About this trial

Last updated 4 months ago

Study ID

2024ZDSYLL044-P01

Status

Recruiting

Type

Observational

Placebo

Accepting

18 to 85 Years

All Sexes

Trial Timing

Started 2 years ago

What is this trial about?

This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.

What are the participation requirements?

Inclusion Criteria

1. age ≥18 years

2. Moderate-to-severe ARDS as per the 2023 ESICM definition

3. Undergoing invasive mechanical ventilation

4. Planned prone position based on the attending physicians' decisions

5. Signed informed consent

Exclusion Criteria

1. age ≥85 years

2. Pregnancy

3. Severe hemodynamic instability (> 30% increase in vasopressors in the last 6 hours or norepinephrine > 0.5 µg/kg/min)

4. Clinically suspected elevated intracranial pressure (>18 mm Hg)

5. Bronchopleural fistula

6. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)

7. Severe hypernatremia (>170mmol/L)

8. Re-admission of patients already enrolled in this study, or patients who are participating in other studies