Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy

- Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days,

- At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or vasopressors administration>12 hours),

- Cumulative UF net less than 1000ml before inclusion,

- Norepinephrine < 0,5 µg/kg/min,

- Absence of hypoperfusion signs,

- Fluid overload defined as follows: fluid overload > 5% of base weight (based on cumulative fluid balance or a weight gain) and/or peripheral edema (AKIKI edema scale > 2).

- Chronic renal failure hemodialyzed before admission to the ICU,

- Mechanical circulatory support (ECMO, LVAD),

- Pregnant, child -bearing age or lactating women,

- Stroke less than 30 days,

- Intestinal ischemia less than 7 days documented non-operated,

- Interventional study participation or exclusion period on going,

- Guardianship, curatorship or safeguard of justice,

- Absence of signature of free and informed consent by the patient and/or relative,

- Patients not affiliated to a social security scheme or beneficiaries of a similar scheme

- Absence of transpulmonary thermodilution monitoring