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Hypermobility, Joint
+2

Exercise in Patients With Hypermobile Joints and Knee Pain

Sponsored by University of Southern Denmark

About this trial

Last updated a year ago

Study ID

RCT_hypermobile_knee

Status

Recruiting

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18 to 45 Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Started a year ago

What is this trial about?

Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.

What are the participation requirements?

Yes

Inclusion Criteria

- Persistent knee pain for ≥ 3 months (self-reported)

- Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)

- Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2/5) (self-reported)

- Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive > 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive > 10 degrees) (objectively measured)

No

Exclusion Criteria

- Diagnosed with patellar tendinopathy

- Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)

- Knee surgery within the past year

- Participation in regular structured resistance training within the past six months

- Inability to speak and understand Danish.

- All types of Ehlers-Danlos syndrome

- Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias

- Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome

- Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis