Oral PEG vs. Enema in Urgent Colonoscopy for ALGIB
Sponsored by Beijing Friendship Hospital
About this trial
Last updated a year ago
Study ID
BFHHZML20240002
Status
Completed
Type
Interventional
Phase
N/A
Placebo
No
Accepting
18+ Years
All Sexes
Trial Timing
Ended a year ago
What is this trial about?
The main goal of this study is to assess whether the diagnostic efficacy of enema is non-inferior to that of oral polyethylene glycol (PEG) in acute lower gastrointestinal bleeding (ALGIB) patients requiring urgent colonoscopy. The secondary objectives include: 1) evaluating potential differences between the enema and oral PEG groups in terms of the difficulty and safety of colonoscopy, as well as exacerbation of bleeding; 2) conducting subgroup analyses to compare the effectiveness of the two bowel preparation methods in specific populations, exploring potential candidate groups for different bowel preparation strategies, and promoting individualized diagnosis and treatment for ALGIB.
What are the participation requirements?
Inclusion Criteria
Patients presenting with hematochezia who were admitted to our hospitals were eligible for the study. Patients were included if they met the following criteria:
1. Had the last bloody bowel movement within 24 hours of presentation;
2. Aged 18 years or over
3. Had indications for clinical colonoscopy
Exclusion Criteria
1. Known or suspected upper gastrointestinal bleeding meeting any of the following criteria:
A. Presence of hematemesis or black vomiting. B. Bloody or coffee nasogastric aspirate. C. Endoscopic evidence of acute upper gastrointestinal bleeding, such as gastric or duodenal ulcer bleeding, esophagogastric variceal bleeding, etc.
2. Previous colonoscopy has been performed at an external institution with a confirmed diagnosis.
3. Presence of primary or secondary coagulation disorders.
4. History of bowel diversion surgery (including partial colon resection).
5. Hemodynamic instability persists after fluid resuscitation (shock index greater than 1).
6. Interventional treatment has been performed and hemostasis has been successfully achieved.
7. Requires transfer to an intensive care unit due to the severity of the condition.
8. Unable to comply with oral polyethylene glycol administration or enema procedures.
9. Known or suspected relative contraindications to colonoscopy, such as toxic megacolon, acute intestinal obstruction, acute myocardial infarction, heart failure, severe liver failure, and end-stage renal disease.
10. Pregnant or lactating women.