The Helix Research Network ("HRN") is a network of academic, public, and/or private
healthcare organizations that are committed to advancing medical research and improving
human health through large-scale genomics research and acceleration of the integration of
genomic and other omics data into clinical care.

Helix Research Network

Genetic Predisposition to Disease

Genetics Disease

The network will create a large-scale clinicogenomics dataset, which will support
research to discover molecular and genetic determinants of disease risk, disease
progression, treatment response, health economic outcomes, social or behavioral
determinants of health, targets for therapeutic intervention, risk stratification,
clinical implementation, and other clinical indicators of interest. This clinicogenomics
dataset will be used to reveal molecular and/or genetic factors that could improve the
diagnosis or medical treatment of individual participants and includes a process to share
individual results with participants. Participants will also receive annual reports on
study outcomes and the impact of HRN, as such information becomes available.

Institutional membership in HRN will consist of Helix and member healthcare systems
(herein referred to as "HRN Member Site(s)"). The Helix Research Network is a
multi-center research program that will enroll an unlimited number of participants.
Participants will be recruited concurrently from HRN Member Sites. In some cases, HRN
Member Sites may recruit participants from multiple clinical sites. Participants who meet
the enrollment criteria established in this protocol will be enrolled if they or their
legally authorized representative(s) provide informed consent in accordance with all
applicable regulations and sIRB requirements. Participants will be enrolled until
withdrawal from the study or end of the study. Participants may be recruited at any point
during the study period, until the recruitment goals established by the protocol are met.

Exome sequencing

Establish a research network to support the advancement of biomedical research, improve
human health through genomics research, and accelerate integration of genomic and other
omics data into clinical care.

Aggregate molecular, genomic data, phenotypic and other health-related data in
centralized and/or federated databases to be accessed by investigators for approved
research purposes.

Recontact participants for additional data collection, research participation
opportunities, and return of results

Identification and characterization of clinical, histological, molecular, and genetic
biomarkers that are linked to disease, disease outcomes, or that might be used to
improvise disease classification.

Exploration of the molecular and genetic underpinnings and determinants of disease,
including disease risk, disease progression, treatment response, health economic
outcomes, social or behavioral determinants of health, targets for therapeutic
intervention, risk stratification, and other clinical indicators of interest.

Collection and analysis of Patient Reported Outcomes (e.g. quality of life, physical
function, symptom burden) associated with diseases that have a genetic or molecular
etiology. Validation of disease-specific instruments to assess the impact of genetic
screening.

Helix Research Network

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?