Aging
+3
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
Sponsored by Ball State University
About this trial
Last updated 2 years ago
Study ID
MitoQ
Status
Completed
Type
Interventional
Phase
N/A
Placebo
Yes
Accepting
18+ Years
All
Trial Timing
Ended 2 years ago
What is this trial about?
The primary goal of this intervention is to determine the efficacy of acute
mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged
and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind,
randomized, placebo-controlled crossover design participants with receive both MitoQ and
placebo arm of the study. Primary endpoints will include vascular endothelial function
assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse
wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by
carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and
elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from
ultrasonography.
What are the participation requirements?
Inclusion Criteria
- Resting brachial blood pressure <160 mmHg (systolic)/<100 mmHg (diastolic)
- Body mass index ≤ 35 kg/m2
- Nonsmoker
- Women must be postmenopausal defined as cessation of menses ≥ 1 year.
Exclusion Criteria
- cardiovascular/metabolic medications
- known clinical disease
- absolute contraindications to exercise testing