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Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging

Sponsored by Ball State University

About this trial

Last updated 2 years ago

Study ID

MitoQ

Status

Completed

Type

Interventional

Phase

N/A

Placebo

Yes

Accepting

18-75 Years
18+ Years
All
All

Trial Timing

Ended 2 years ago

What is this trial about?

The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.

What are the participation requirements?

Yes

Inclusion Criteria

- Resting brachial blood pressure <160 mmHg (systolic)/<100 mmHg (diastolic)

- Body mass index ≤ 35 kg/m2

- Nonsmoker

- Women must be postmenopausal defined as cessation of menses ≥ 1 year.

No

Exclusion Criteria

- cardiovascular/metabolic medications

- known clinical disease

- absolute contraindications to exercise testing

Locations

Location

Status