Comparison between tamsulosin and Tadalafil in management of benign prostatic hyperplasia
A Randomised Trial

Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study

Assessment of the discontinuation rate of tamsulosin and tadalafil after 12 months follow
up either and evaluate the changes in urinary parameters and sexual parameters in
patients with lower urinary tract symptoms due to BPH concomitant with erectile
dysfunction. We tried to overcome the limitations of the previous studies by designing a
prospective randomized controlled trial as the present study is the first randomized
controlled trial that evaluate the safety, discontinuation rate and efficacy of tadalafil
compared with tamsulosin for long term follow up (12 months).

Tamsulosin

Tadalafil

Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia A Randomised Trial

drug discontinuation rate either : lack of response, adverse events or poor compliance

detect the improvement in International Prostate Symptom Score (IPSS) . The IPSS is made
up of 7 questions related to voiding symptoms. A score of 0 to 7 indicates mild symptoms,
8 to 19 indicates moderate symptoms and 20 to 35 indicates severe symptoms

detect the changes in maximum flow rate (Q max) as Qmax below 10 ml /sec is obstructed
flow curve , between 10 to 15 ml / sec is equivocal and above 15 ml/ sec is normal

measured by pelvic ultrasound after micturation to detect the amount of residual urine in
milliliter.

changes in International Index of Erectile Function(IIEF) . IIEF questionnaire is
classified as : No erectile dysfunction (26-30points), Mild ED (score 22-25), Mild to
moderate (17-21), Moderate ED (score 11-16), Severe ED (score ≤ 10)

patients with benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) treated by
tamsulosin with 12 months follow up

patients with benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) treated by
tadalafil 5 mg with 12 months follow up

Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status