The investigators will test the hypothesis that patients with chronic orthostatic intolerance
      or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary
      sodium as compared to healthy control subjects.

Acute Salt Handling in Orthostatic Intolerance

Postural Tachycardia Syndrome

Orthostatic Tachycardia

Orthostatic Intolerance

Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that
      regulate salt & water handling. Increases in dietary salt have salutary effects on
      orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline
      acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt
      suggests abnormal salt handling in patients with chronic OI in a few patients. These data
      need to be confirmed and a better understanding of sodium handling in response to acute salt
      loads is required in these patients.

Acute Salt Handling in Orthostatic Intolerance

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?