No trials have evaluated the effect of a Midazolam bolus (routinely used for premedication
      before general anesthesia) on the Concnetration at the effector site of Propofol (CeP) of
      Eleveld and Schnider TCI models, routinely used for general anesthesia delivery.

Effect of Midazolam Bolus on Eleveld and Schnider TCI (Target Controlled Infusion) Models

Propofol

Anesthesia Brain Monitoring

During recent years Eleveld and colleagues ideated a new propofol
      pharmacokinetic/pharmacodynamic (PK/PD) model for total intravenous anaesthesia with target
      controlled infusion (TIVA-TCI) pumps that has been proposed to have slightly better
      predictive performance for measured propofol plasma concentrations compared with those of the
      Marsh and Schnider models, and suitable for children, adults, older subjects, and obese
      adults, being considered as a "General purpose" model.

      However, no trials have compared the Eleveld to the Schnidermodel after a premedication with
      Midazolam bolus (0.03 mg/kg) from a clinical point of view; so, this study aimed toevaluate
      midazolam effect on the estimated effector site concentration of the two models (CePE and
      CePS, respectively) at loss of responsiveness (LoR), during anaesthesia maintenance
      (Bispectral Index [BIS] 40-60) and return of responsiveness (RoR). The study also compared
      the incidence of deepening or superficializing anaesthesia (defined respectively as lowering
      or increasing in out-of-target BIS after initial CeP detection), as well as unwanted
      anaesthesia events: burst suppression (BSupp, identified as a burst suppression ratio [BSR]
      >0) and unwanted spontaneous responsiveness.

Clinical Comparison Between Two Propofol TCI Models(Eleveld and Schnider) for General Anaesthesia After Premedication With Midazolam

Discover if, after astandard premedication with midazolam bolus, there are differences between Concentrations at the effector site of Propofol using the Eleveld TCI model versus Schnider TCI model, during standard general anaesthesia conducted with Propofol and remifenatnil delivered with targeted controlled infusion pumps, usually adopted in our Hospital to delivery general anaesthesia

MD, Principal investigator

Patients who received Midazolam premedication bolus (0.03 mg/kg) before general anesthesia conducted with Eleveld TCI model (this model was choosen at anesthesiologist's discreption)

Patients who received Midazolam premedication bolus (0.03 mg/kg) before general anesthesia conducted with SchniderTCI model (this model was choosen at anesthesiologist's discreption)

Effect of Midazolam Bolus on Eleveld and Schnider TCI (Target Controlled Infusion) Models

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status