Takotsubo Syndrome and Air Pollution
Sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
About this trial
Last updated 2 years ago
Study ID
5290
Status
Recruiting
Type
Observational
Placebo
No
Accepting
18+ Years
All
Not accepting
Healthy Volunteers
Trial Timing
Started 3 years ago
What is this trial about?
Takotsubo syndrome (TTS) is an acute and reversible form of myocardial injury characterized
by typical regional wall motion abnormalities in the absence of culprit epicardial coronary
artery disease frequently precipitated by significant emotional stress or serious physical
illness. The clinical presentation is usually similar to acute myocardial infarction (MI),
with chest pain and/or dyspnea, ST-segment elevation or depression and/or T-wave inversion on
the resting electrocardiogram (ECG) and elevation of serum cardiac troponin. Although
previously considered a benign disease, it is now clear that TTS is associated with severe
acute complications during the acute phase including hemodynamic and electrical instability
and up to 5% of in-hospital mortality.
The pathogenetic mechanisms of air pollution are likely to predispose to the occurrence as
well as to mediate a worse clinical presentation and outcome of TTS, proving air pollution as
a TTS risk factor.
What are the participation requirements?
Inclusion Criteria
- Age ≥18 years.
- Diagnosis of TTS.
- Available data for short-term and/or long-term exposure to air pollutants (see below).
- Written informed consent to participate.
Exclusion Criteria
- Age <18 years.
- Not available data for short-term and/or long-term exposure to air pollutants.
Locations
Location
Status
Recruiting