Detection of Coronary Artery Calcifications by Whole Blood Transcriptome Analyzed by Artificial InTelligence Algorithms

- Men and women between 30 and 75 years attending the institution for a non-contrast cardiac CT scan (coronary calcium score) either by medical indication or voluntary for cardiovascular risk assessment.

- Signature of the informed consent form

- Previously known chronic renal or hepatic insufficiency.

- Active chronic lung disease, defined as exacerbated asthma, exacerbated chronic obstructive pulmonary disease (COPD), or pulmonary fibrosis.

- Active and/or previous cardiovascular disease, defined as previous acute myocardial infarction, stable or unstable angina, cerebrovascular accident, history of vascular interventions (coronary or another territory), heart failure, severe cardiomyopathies, or valvulopathies.

- Uncontrolled hyper or hypothyroidism.

- Suprarenal insufficiency.

- Previous surgeries in the last 3 months.

- Severe trauma in the last 6 months, defined as one that involved bone fractures and/or surgical interventions.

- Known active cancer disease or under treatment (acute or preventive), or history of cancer disease without criteria for a cure.

- Known autoimmune disease active or in treatment.

- Ongoing pregnancy, postpartum period of fewer than 12 months, or breastfeeding.

- Other serious illnesses with an estimated life expectancy of fewer than 12 months (according to the investigators).

- Temperature greater than 37.5°C recorded by a thermometer or any acute infection caused by viruses or bacteria confirmed by a health professional in the previous 30 days.

- Pathologies under immunosuppressive treatment