Study of Novel Antiretrovirals in Participants With HIV-1

Key Inclusion Criteria:

All Substudies:

- Plasma human immunodeficiency virus-1 (HIV-1) ribonucleic acid (RNA) ≥ 5000 copies/mL
but ≤ 400,000 copies/mL at screening.

- Cluster of differentiation 4 (CD4) cell count > 200 cells/mm^3 at screening.

- Antiretroviral (ARV) treatment-naive or treatment-experienced but naive to the
investigational ARV drug class being investigated in the given substudy and have not
received any ARV within 12 weeks of screening, including medications received for
pre-exposure prophylaxis (PrEP) or postexposure prophylaxis (PEP) (note that current
or prior receipt of long acting (LA) parenteral ARVs such as monoclonal antibodies
(mAbs) targeting HIV-1, injectable cabotegravir (CAB), or injectable rilpivirine (RPV)
is exclusionary).

- Have adequate renal function (estimated glomerular filtration rate (eGFR) ≥ 70
mL/min/1.73 m^2)

- No clinically significant abnormalities in electrocardiogram (ECG) at screening.

Substudy-01 and Substudy-02:

- Participants in substudy-01 should be willing to initiate a non-NNRTI based SOC ART on
Day 11.

- Participants in substudy-02 should be willing to initiate any SOC ART on Day 11.

- Willing and able to comply with meal requirements on dosing days.

Key Exclusion Criteria:

All Substudies:

- Known historical genotypic or phenotypic resistance to 4 major ARV classes (nucleoside
reverse transcriptase inhibitor (NRTI), nonnucleoside reverse transcriptase inhibitor
(NNRTI), protease inhibitor (PI), integrase strand-transfer inhibitor (INSTI)).

- History of an AIDS-defining condition including present at the time of screening.

- Active, serious infections (other than HIV-1) requiring therapy and including active
tuberculosis infection < 30 days prior to randomization.

- History of or current clinical decompensated liver cirrhosis (eg, ascites,
encephalopathy, or variceal bleeding).

- Any other serious or active clinical condition or prior therapy that, in the opinion
of the investigator, would make the individual unsuitable for the study or unable to
comply with dosing requirements.

- Hepatitis C virus (HCV) antibody positive and detectable HCV RNA.

- Chronic hepatitis B virus (HBV) infection, as determined by either:

- Positive HBV surface antigen and negative HBV surface antibody, regardless of HBV
core antibody status, at the screening visit, or

- Positive HBV core antibody and negative HBV surface antibody, regardless of HBV
surface antigen status, at the screening visit.

- Hepatic transaminases (aspartate aminotransferase (AST) or alanine aminotransferase
(ALT)) > 5 x upper limit of normal (ULN).

- Current alcohol or substance use judged by the investigator to potentially interfere
with individual study compliance.

- Positive serum pregnancy test at screening or a positive pregnancy test prior to Day
1.

- Individuals with plan to breastfeed during the study period including the
protocol-defined follow-up period.

- Requirement for ongoing therapy with or prior use of any prohibited medications listed
in the protocol. Any prescription medications or over the counter medications,
including herbal products, within 28 days prior to start of study drug dosing must be
reviewed and approved by the sponsor, with the exception of vitamins and/or
acetaminophen and/or ibuprofen.

- Any current or prior receipt of LA parenteral ARVs such as mAbs targeting HIV-1,
injectable CAB, or injectable RPV, for treatment or prophylaxis (PrEP, PEP).

Substudy-01 and Substudy-02:

- Requirement for ongoing therapy with any prohibited medications listed in protocol.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.