Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
Sponsored by Thomas Engstrom
About this trial
Last updated 2 years ago
Study ID
Status
Type
Phase
Placebo
Accepting
Not accepting
Trial Timing
Ended 8 months ago
What is this trial about?
What are the participation requirements?
Inclusion Criteria
1. Age ≥18 years including fertile women (It is not possible to perform a pregnancy test (HCG urine test) in the pre-hospital setting. However, methylprednisolone is not contraindicated in pregnant women).
2. Acute onset of chest pain with < 12 hours duration.
3. STEMI as characterized on electrocardiogram (ECG) by one of the following: 1) at least two contiguous leads with ST-segment elevation ≥2.5 mm in men < 40 years, ≥2 mm in men ≥40 years, or ≥1.5 mm in women in leads V2-V3 and/or ≥1 mm in the other leads, 2) presumed new left bundle branch block with ≥1 mm concordant ST-segment ele-vation in leads with a positive QRS complex, or concordant ST-segment depression ≥1 mm in V1-V3, or discordant ST-segment elevation ≥5 mm in leads with a negative QRS complex, 3) Isolated ST depression ≥0.5 mm in leads V1-V3 and ST-segment elevation (≥0.5 mm) in posterior chest wall leads V7-V9 indicating posterior acute myocardial infarc-tion (AMI), 4) ST-segment depression ≥1 mm in eight or more surface leads, coupled with ST-segment elevation in aVR and/or V1 suggesting left main-, or left main equivalent- coronary obstruction.
Exclusion Criteria
1. Presentation with cardiac arrest (out of hospital cardiac arrest (OHCA)).
2. Time from symptoms onset to primary PCI > 12 hours.
3. Known allergy to glucocorticoid or known mental illness with maniac or psychotic episodes.
4. Patients with previous acute myocardial infarction (AMI) in the assumed culprit artery.
5. Previous coronary artery bypass graft (CABG).
6. Unable to read and understand Danish.