INSPIRE Trial for Skin and Soft Tissue Infections
Sponsored by Harvard Pilgrim Health Care
About this trial
Last updated 3 years ago
Study ID
PH000763B_SST
Status
Recruiting
Type
Interventional
Phase
N/A
Placebo
No
Accepting
18+ Years
All
Not accepting
Healthy Volunteers
Trial Timing
Started 3 years ago
What is this trial about?
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of
HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with
real-time, precision medicine computerized physician order entry (CPOE) smart prompts
providing the probability that a non-critically ill adult admitted with skin and soft tissue
infection is infected with a resistant pathogen.
Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been
randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if
they shared campuses or antibiotic stewardship staff.
What are the Participation Requirements?
Facility Inclusion Criteria:
1. HCA Healthcare hospitals admitting adults for skin and soft tissue infection
2. Facility use of MEDITECH as their electronic health record system
Facility Exclusion Criteria:
-
Note: unit of randomization is the hospital, however the computerized physician order entry
(CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to
non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics
for skin and soft tissue infection.