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Safety Issues

Effect of Different Ingestion Doses of Celastrol on Human Sperm Motility

Sponsored by Legend Labz, Inc.

About this trial

Last updated 3 years ago

Study ID

AMT-001-2021

Status

Recruiting

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18 to 40 Years
Male
Male

Trial Timing

Ended 3 years ago

What is this trial about?

Five healthy participants with normal sperm counts and motility will ingest increasing doses of celastrol over a period of several days. After each dose ingestion the participants will provide an ejaculate the next day for sperm analysis. The objective is to see if increasing ingestion levels of celastrol will affect the sperm counts and motility of the participants.

What are the participation requirements?

Yes

Inclusion Criteria

1. Individuals who are between 18 and 40 years of age and who are found to be healthy without any underlying medical conditions that could affect sperm motility, and are not taking any daily medications. This does not exclude patients who take drugs prn.

2. Individuals who have not be involved in other clinical trials during the last 90 days. -

No

Exclusion Criteria

1. Individuals who have been involved in any other clinical trial during the last 90 days.

2. Individuals who have sperm counts lower than that considered "normal." i.e. a sperm count of ~20 million sperm per milliliter of ejaculate, and (b) sperm motility of ≥ 40% one hour after ejaculate.

3. Clinically significant cardiac disease including uncontrolled congestive heart failure and unstable angina

4. Individuals on medications that the clinician feels may affect sperm motility and/or otherwise interfere with the results

5. Medications that might interfere with blood chemistry, or CBCs

6. Subjects who are taking daily medications. The use of therapies prn is allowed.

7. Subjects Less than 18 years of age or over 40 years of age

8. Prisoners

9. Subjects who have taken anabolic steroid or testosterone during the last six months.

10. Subjects with a current history of addictive alcohol or illegal drug abuse (e.g. cocaine, heroin, etc.). The use of marijuana is allowed, but not preferred.

11. Subjects who are taking 5-alpha-reductase inhibitors (finasteride (Propecia®) and dutasteride (Avodart®), or Chemotherapy: -

12. Smokers

Locations

Location

Status

Recruiting