Effectiveness of Concurrent Ultra-Low-Dose Total-Skin Electron Beam Therapy and Brentuximab Vedotin Given Quarterly Over 12 Months for Patients With Mycosis Fungoides

1. Biopsy-confirmed mycosis fungoides in stage I-IV (APPENDICES 3 AND 4); the presence of Sezary cells in the blood is acceptable at original diagnosis or at enrollment into the protocol, as long as the patient has current mycosis fungoides in the skin and the sesary cells in peripheral blood are < 1000 cells/ microlitre at the time of enrollment.

2. Patients with relapsed/refractory mycosis fungoides, who have ever expressed or currently express at least 1% CD30 assessed by biopsy within 6 months prior to study enrollment, are eligible.

3. Previous systemic anticancer therapy must have been discontinued at least 1 week before treatment

4. Topical or systemic steroids (equivalent to 10 mg/day of prednisone) may be considered if the dose of such steroids has been constant and their discontinuation may lead to rebound flare in disease, adrenal insufficiency, and/or unnecessary suffering, after discussion with the Principal Investigator.

5. 18 years of age or older

6. Eastern Cooperative Oncology Group (ECOG) performance status score of ≤ 3 (APPENDIX 5)

7. No required wash-out period for prior therapies

8. HIV+ patients must be on stable antiretroviral treatment for 12 weeks before the first day of cycle 1 (C1D1), with CD4 count >200 within the 7 days before C1D1.

9. Ability to understand and the willingness to sign a written informed consent document.

1. Concurrent use of other systemic anticancer agents or treatments for mycosis fungoides or Sezary syndrome

2. Grade 2 or greater neuropathy

3. Severe renal impairment (creatinine clearance [CrCL] <30 mL/min)

4. Moderate or severe hepatic impairment (Child-Pugh B or C; see APPENDIX 6 for ChildPugh classification chart)

5. Women of reproductive potential must have a negative serum ß human chorionic gonadotropin (ß-HCG) pregnancy test within 1 week of C1D1. They should discuss contraception with the treating provider. And agree to use adequate birth control measures (oral, implanted, or barrier methods) while on study

6. Receipt of systemic therapy for another primary malignancy (other than T-cell lymphoma). Patients with more than one type of lymphoma may be enrolled after discussion with the Principal Investigator

7. Underlying medical conditions including unstable cardiac disease, or other serious illness that would impair the ability of patient to undergo treatment

8. Any other medical history, including laboratory results, deemed by the Principal Investigator to be likely to interfere with patient participation in the study