Clinical Study of XPO-1 Inhibitors Plus CAR-T Cells in Relapsed Refractory B-cell Non-Hodgkin's Lymphoma

1. Age ≥ 18 years.

2. Pathological immunohistochemistry or flow cytometry confirmed that R/ R B-cell Non-Hodgkin's Lymphoma with measurable (diameter greater than 1.5cm) lesions meets any of the following conditions: 1> After 4 courses of standard first-line therapy or 2 courses of more than two-line therapy, the lesions were reduced by <50%; 2> R/ R B-cell Non-Hodgkin's Lymphoma with disease progression after first-line or induction therapy; 3> After hematopoietic stem cell transplantation, new lesions appear or the size of previously affected lesions increased by more than 50%.

3. Previously treated with 2 or more lines of therapy.

4. ECOG≤2#.

5. The main organ functions need to meet the following conditions:LVEF≥50%;CR≤132 umol/l or CCr≥60 ml/min; ALT and AST≤2.5 times normal range#TB≤2 times ULN#Lung function≤Level 1; dyspnea(CTCAE v5.0),and blood oxygen saturation without oxygen absorption> 90%.

6. Pass the T-cell amplification test.

7. Voluntary tissue puncture/biopsy for tumor tissue retrieval before and after treatment.

8. Subjects of child-bearing or child-fathering potential must be willing to practice birth control from the time of enrollment on this study until the follow-up one year period of the study.

9. Estimated survival time ≥3 months.

10. Voluntary signing of informed consent and good compliance.

1. Have used immunosuppressants or hormones within 2 weeks prior to signing informed consent, or plan to have to use immunosuppressants or high-dose hormones (e.g. prednisone >15mg) after signing informed consent, specifically systemic treatment, excluding treatment with topical or inhaled corticosteroids.

2. The presence of bacterial, fungal, viral, mycoplasma or other types of infection that, in the judgment of the investigator, are difficult to control.

3. Active hepatitis B or active hepatitis C.

4. HIV infection.

5. Active acute or chronic graft-versus-host disease (GVHD) at the time of signing the informed consent form.

6. Participated in an investigational clinical trial of any other drug within 30 days prior to signing the informed consent form.

7. Received CAR-T cell therapy within 3 months prior to signing the informed consent form.

8. Received an allogeneic hematopoietic stem cell transplant within 6 months prior to signing the informed consent form.

9. Presence of contraindications to XPO-1 inhibitor.

10. Prior malignancy (other than Relapsed Refractory B-cell Non-Hodgkin's Lymphoma), except for cured malignant tumors with no active lesions for 3 years;Adequate treatment of inactive lesions in non-melanoma skin cancer,malignant tonsilloma or carcinoma in situ.

11. Pregnant or breasting-feeding women.

12. Conditions deemed by the researcher to be inappropriate for participation in this clinical trial.