Keto Drinks as a Meal Primer in Patients With Type 2 Diabetes
Sponsored by University of Aarhus
About this trial
Last updated 2 years ago
Study ID
1-10-72-282-20
Status
Completed
Type
Interventional
Phase
N/A
Placebo
No
Accepting
18+ Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended 3 years ago
What is this trial about?
The main objective of this clinical trial is to study the effects of orally administered
ketone drinks containing the ketone body, 3-hydroxybutyrate (3-OHB), just before a meal in
patients with type 2 diabetes. Moreover the investigators will compare the effects of two
different ketone drinks.
The hypothesis is:
3-OHB as a pre-meal may:
- Lower postprandial blood glucose and lipids.
- Mediate release of intestinal hormones and affect gastric emptying.
- Affect appetite and other subjective measures related to food intake.
The effects of 3-OHB as a pre-meal will be investigated by blood samples, isotopic tracers
examinations, paracetamol test, questionnaires and meal test.
What are the participation requirements?
Inclusion Criteria
- Type 2 diabetes diagnosis, metformin treated or dietary treated
- HbA1C < 80 mmol/mol
- 25 < BMI < 35
- Written consent
Exclusion Criteria
- Severe comorbidity
- Treatment with insulin, GLP-1 analogues, SGLT-2-inhibitors or sulfonylureas
- Specific diets, e.g. ketogenic diet
- PI finds the patient not fit (e.g. mental illness, too nervous, unacceptable screening blood tests or other)