to analyze the changes in corneal biomechanics of myopic children with different
treatment (low concentration atropine eye drops and orthokeratology) and explore the
possible mechanism of myopia control

Influence of Corneal Biomechanical Properties on Myopia Control

Myopia

High myopia is accompanied by excessive growth of eyeball, which leads to many
complications. Myopia control is a great concern of the government and ophthalmologists
worldwide.

Atropine eye drops is used clinically to control the progression of myopia. In recent
years, low dose Atropine eye drops (0.01%, 0.05% and 0.1%) have been proven to be
effective in slowing growth of eyeball. With less negative effects, these eye drops have
been widely used for school children in Taiwan. Orthokeratology is another effective tool
to control myopia, and long-term wearing of Ortho-k lens can inhibit the speed of eyeball
growth, it is the most useful optical treatment for myopia control.

The Corvis® ST is a combination of an air pulse tonometer with an ultra-high-speed
Scheimpflug camera. The movement of the cornea is mainly influenced by three factors
which can be measured by the instrument:

Intraocular pressure (IOP)，biomechanical properties of the cornea and corneal thickness.
The relationship between adult corneal biomechanics and refractive error has been noted
in recent years. Previous studies pointed out that corneal biomechanics analyzer (Corvis
ST) can measure the deformation process of the cornea and the biomechanics parameters.
These literature found that the corneas of myopic patients， esp. high myopic, have larger
corneal deformation in biomechanics analysis and revealed that the corneal stiffness of
myopia patients was lower. There are still few discussions about the effect of
orthokeratology on corneal biomechanics and there is no research focused on the change of
corneal biomechanics of low-concentration atropine user which is worthy of our further
exploration.

In this study, the investigators hope to analyze the changes in corneal biomechanics of
myopic children with different treatment (low concentration atropine eye drops and
orthokeratology) and explore the possible mechanism of myopia control.

orthokeratology

0.01 atropine

Influence of Corneal Biomechanical Properties on Myopia Reduction and Axial Elongation in Children Using Orthokeratology and 0.01% Atropine

the investigators measure the intraocular pressure(IOP, mmHg) of myopic children with
different treatment (low concentration atropine eye drops and orthokeratology)

the investigators measure the visual acuity of myopic children with different treatment
(low concentration atropine eye drops and orthokeratology).

the the investigators measure the central corneal thickness(CCT, micrometer, ㎛) of myopic
children with different treatment (low concentration atropine eye drops and
orthokeratology) by Corvis ST machine

the the investigators measure the corneal biomechanics index (CBI) of myopic children
with different treatment (low concentration atropine eye drops and orthokeratology) by
Corvis ST machine

the the investigators measure the stress-strain index (SSI) of myopic children with
different treatment (low concentration atropine eye drops and orthokeratology) by Corvis
ST machine

the investigators measure the axial length(mm) of eyeball of myopic children with
different treatment (low concentration atropine eye drops and orthokeratology).

Myopic children use overnight orthokeratology or 0.01% atropine eye drop per night for
myopia control

Influence of Corneal Biomechanical Properties on Myopia Control

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status