Registry for Women Who Are At Risk Or May Have Lynch Syndrome
Sponsored by M.D. Anderson Cancer Center
About this trial
Last updated 2 years ago
Study ID
2006-0973
Status
Completed
Type
Observational
Placebo
No
Accepting
18+ Years
Female
Trial Timing
Ended 2 years ago
What is this trial about?
The goal of this study is to create a registry of information about women who have or are at risk for Lynch syndrome, in order to study gynecologic cancer risks.
This is an investigational study. Up to 1000 patients will take part in this study. All patients will be enrolled at MD Anderson.
What are the participation requirements?
Inclusion Criteria
1. Women who meet one or more of the following criteria : A.Lynch syndrome mutation, including those at risk for cancer, those who have had cancer, and those who have had prophylactic surgery. B. Family history meets Amsterdam II criteria, defined as the following: At least 3 relatives with an HNPCC-associated cancer (colorectal.endometrial cancer, small bowel, ureter, or renal pelvis).One is a first-degree relative of the other two. At least 2 successive generations affected. One cancer diagnosed before age 50.C. Tumor studies (MSI, IHC) are suggestive for Lynch Syndrome.
2. D. Female family members who are at 25% or 50% risk for a lynch syndrome mutation may also be enrolled in the registry. 25% risk is defined as women with second degree family member grandmother, aunt, uncle, niece, and grandchild. 50% risk is defined as women with first degree family member being parent, child, sibling.
3. Subjects must be 18 or older and able to give informed consent.
Exclusion Criteria
1) None