Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central
nervous system frequently affecting females in their reproductive phase of life. In this
prospective observational study, we obtain data on the outcome of pregnancies in MS
patients and the influence of pregnancy on clinical, laboratory and MRI parameters in MS.

Pregnancy Cohort in Multiple Sclerosis (MS)

Multiple Sclerosis (MS)

Clinically Isolated Syndrome (CIS)

Time (in days) until relapse during the observation period

Principal Investigator

Number of T2 lesions in spinal and cerebral magnetic resonance imaging

Number of gadolinium enhancing lesions in spinal and cerebral magnetic resonance imaging

Volume of T2 lesions in spinal and cerebral magnetic resonance imaging

Volume of gadolinium enhancing lesions in spinal and cerebral magnetic resonance imaging

Change in immune cell phenotypes of peripheral blood mononuclear cells (PBMC)

Change in serum galectin-1 concentration measured by ELISA

Change in serum galectin-3 concentration measured by ELISA

Change in serum galectin-9 concentration measured by ELISA

Change in neurofilament serum concentration by using Simoa NfL assay

Change in interleukin-17 serum concentration assessed by ELISA

Change in anti-inflammatory interleukin-10 serum concentration assessed by ELISA

Identification and quantification of autoantibodies by using protein microarray and ELISA

Composition of fecal microbiome measured by 16S Sequencing

Thickness of the retinal nerve fibre layer by Optical Coherence Tomography (OCT)

Total macular volume by Optical Coherence Tomography (OCT)

Structured diagnostic interview to assess depression, dysthymia and suicidality

Rating of ten depression related symptoms on a scale from 0 to 6 (higher numbers indicate
more severe symptoms)

Rating of 21 depression related symptoms on a scale from 0 to 3 (higher numbers indicate
more severe symptoms)

Self-report survey containing 10 items, each item is rated 0-3 (higher scores indicate a
higher probability of postpartum depression)

Self-report survey containing 21 items, each item is rated 0-4 (higher scores indicate a
greater impact of fatigue on a person's activities)

A self-report survey consisting of 11 items, each item ranges from 1 to 7 (higher scores
indicate higher levels of fatigue)

A self-administered, single scale indication measuring visual fatigue, ranging from 0 to
100 (higher scores indicate worse fatigue)

A self-report survey measuring health in eight dimensions (higher scores indicate less
disability)

Patients with clinically isolated syndrome, relapsing-remitting or progressive multiple
sclerosis

Pregnancy Cohort in Multiple Sclerosis (MS)

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status