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Compensated Advanced Chronic Liver Di...

CHESS-SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease (CHESS2102)

Sponsored by Hepatopancreatobiliary Surgery Institute of Gansu Province

About this trial

Last updated 4 years ago

Study ID

CHESS2102

Status

Unknown status

Type

Observational

Placebo

No

Accepting

18-75 Years
18+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 4 years ago

What is this trial about?

Compensated advanced chronic liver disease (cACLD) was associated with a high rate of variceal bleeding, ascites, and hepatic encephalopathy due to portal hypertension. In these patients, esophagogastroduodenoscopy and hepatic venous pressure gradient were recommended methods to evaluate portal hypertension. However, non-invasive predictors of outcomes to stratify care remains needed. Although the updated EASL guideline has recommended that patients with liver stiffness >20kPa or platelets <150*10^9/L had the high risk of decompensation, the criteria remains to be validated. This international multicenter study aims to develop a novel CHESS-SAVE score to further predict the risk of liver decompensation in cACLD patients.

What are the Participation Requirements?

Training and validation cohort

Inclusion Criteria:

- age more than 18 years;

- fulfilled diagnosis of cACLD based on radiological, histological features of liver
cirrhosis

Exclusion Criteria:

- prior liver decompensation;

- hepatocellular carcinoma;

- prior liver transplantation;

- portal vein thrombosis;

- antiplatelet or anticoagulation;

- without screening EGD within six months of TE;

- incomplete follow-up data.

HVPG cohort

Inclusion Criteria:

- age more than 18 years;

- fulfilled diagnosis of cACLD based on radiological, histological features of liver
cirrhosis

Exclusion Criteria:

- prior liver decompensation;

- hepatocellular carcinoma;

- prior liver transplantation;

- portal vein thrombosis;

- antiplatelet or anticoagulation;

- without screening EGD within six months of TE;

- without HVPG measurement;

- non-sinusoidal portal hypertension.

Locations

Location

Status