This study is to examine whether group-based Acceptance and Commitment Therapy in the
      patient-caregiver dyads with Chronic Heart Failure is effective in improving dyadic
      health-related quality of life, dyadic psychological symptoms, caregiver burden, the rate of
      patient's readmission, and patient's self-care behavior in comparison with those dyads
      receiving health education over three-month post intervention.

Acceptance and Commitment Therapy for Patients With Chronic Heart Failure and Their Caregivers on Their Quality of Life

Chronic Heart Failure

Chronic heart failure (CHF) is a complex progressive debilitating illness characterized by
      high morbidity and mortality with unpredictable course and frequent hospital readmissions.
      Patients with CHF are often old with comorbid impaired psychosocial functioning, and worse
      health-related quality of life (HRQoL), which generate unavoidable increased dependence on
      their family caregivers at home. The family caregivers often bear physical and psychological
      challenges with declined HRQoL, maintaining interdependent relationships with their care
      recipient when participating in CHF self-management. Dyadic interventions delivered to the
      patients along with their family caregivers are successful to facilitate patients'
      self-management to reduce patients' hospital readmission rates and improve HRQoL for both
      patients and their caregivers post-discharge in the context of chronic disease management.
      However, little attention has been paid to this vulnerable group. It is noteworthy that a
      transdiagnostic psychological approach, Acceptance and Commitment Therapy (ACT), aiming to
      promote psychological flexibility, has demonstrated an ability to break through the
      psychological barriers to meaningful living among clinical and non-clinical populations.
      Existing evidence shows promising improvements of ACT on HRQoL in both patients with chronic
      illness and the family caregivers of the patients with childhood illness. Such evidence
      implies that ACT in the patient-caregiver dyads may be beneficial for HRQoL and other health
      outcomes for both patients with CHF and their family caregivers. However, little has been
      done to address these concerns in mainland China.

      A pilot testing was to evaluate the feasibility of recruiting participants at the clinical
      setting and the acceptability of group-based ACT to patient-caregiver dyads with CHF. Then, a
      pragmatic, single-center, two-arm, parallel (in 1:1 ratio) randomized controlled trial (RCT)
      will be performed to examine the effects of acceptance and commitment therapy in
      patient-caregiver dyads with CHF. Eligible patient-caregiver dyads will be randomly assigned
      to either the intervention group or the control group. Assessments will be conducted before
      the intervention, immediately post-intervention, and 3-month post-intervention by blind
      outcome assessors. The ACT intervention will be delivered by two facilitators and continually
      supervised by an experienced ACT researcher.

ACT (Acceptance and Commitment Therapy) plus brief CHF education

HE (Health Education)

Effectiveness of Acceptance and Commitment Therapy on the Health-related Quality of Life in Patients With Chronic Heart Failure and Their Family Caregivers: A Randomized Controlled Trial

The short-form Kansas City Cardiomyopathy Questionnaire (KCCQ-12) will be used for patients. KCCQ-12 is a 12-item instrument with a score of 0-100, a lower score indicates a poorer quality of life.

The five-dimensional descriptive system of the EuroQol Group 5-Dimension questionnaire (EQ-5D-5L) will be used to evaluate generic health-related quality of life for patients. The scores range from less than 0 to 1.0, with higher scores representing higher health utility.

The five-dimensional descriptive system of the EuroQol Group 5-Dimension questionnaire (EQ-5D-5L) will be used to evaluate generic health-related quality of life for caregivers. The scores range from less than 0 to 1.0, with higher scores representing higher health utility.

Patients' report of the total number of unscheduled readmission and emergency visits due to heart-related problems in either a / public hospital(s) and/or a private hospital(s)

The European Heart Failure Self-care Behavior Scale (EHFScBS) will be used for patients to evaluate their self-care behavior. EHFScBS is a 12-item 5-point Likert scale with a score ranging from 0 to 60, a lower score represents a higher level of self-care behaviors.

Patients' report of not having/ having smoked and the estimated amount of cigarette consumed (if applicable) for the past one week.

Patients' report of not having/ having alcohol drinking and the estimated amount of alcohol consumed (if applicable) for the past one week.

The Zarit Caregiver Burden Interview (ZBI) will be used for caregivers to evaluate perceived care burden. ZBI is a 22-item 5-point Likert scale with a score ranging from 0 to 88, a lower score indicates less care burden.

The General Anxiety Disorder Scale (GAD) will be used for caregivers and patients. The GAD consists of 7 item 4-point Likert scale. The score of each scale ranges from 0 to 21, with a lower score indicating a lower level of anxiety.

The Patient Health Questionaire (PHQ) will be used for caregivers and patients. The PHQ consists of 9 item 4-point Likert scale. The score of each scale ranges from 0 to 27, with a lower score indicating a lower level of depression.

The perspective taking subscale from the Interpersonall Reactivity Index (IRI) will be used for caregivers and patients. Chinese version of the perspective taking subscale is a 5-item 5-point Likert scale with a score ranging from 5 to 25, a lower score represents a lower tendency for perspective taking.

The Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) will be used for caregivers and patients.CompACT is an 18-item 5-point Likert scale with a score ranging from 18 to 90, a lower score represents a lower level of psychological flexibility.

The Dyadic Adjustment Scale-7(DAS-7) will be used for caregivers and patients.DAS-7 is a 7-item 6-point Likert scale with a score ranging from 0 to 36, a lower score represents less positive relationship quality.

The visual analog scale (VAS) of EuroQol Group 5-Dimension questionnaire (EQ-5D-5L) will be used to evaluate participants' perceived health, the score ranges from 0 to 100 with 100 being better.

The Self-compassion Scale (SCS) will be used for caregivers and patients.SCS is an 12-item 5-point Likert scale with a score ranging from 12 to 60, a lower score represents a lower level of self-compassion.

The ACT intervention was structured to take place over one month on a weekly basis via Tencent's VooV platform. Each roughly 2-hour session will consist of a group-based ACT (1.5 hours) and a brief health education talk on CHF self-management (0.5 hours). Each training session will serve about 4-8 dyads. In addition, each participant will receive one set of session handouts on CHF education, ACT skills, and a homework assignment.

The participants of the control group will receive four weekly 2-hour sessions of structured health education on CHF self-management over four consecutive weeks via Tencent's VooV platform, delivered by a registered nurse. Each session will includea a review of the previous session (except the first session), a CHF education talk and a Q&A section to evaluate the participant's understanding of the key concepts. Each session will be offered to 4-8 patient-caregiver dyads. In addition, each participant will receive session handouts on the main topic related to CHF self-management and homework assignments.

Acceptance and Commitment Therapy for Patients With Chronic Heart Failure and Their Caregivers on Their Quality of Life

About this trial

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Placebo

Accepting

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