Post-operative monitoring of all patients after anaesthesia in the post anaesthesia care
unit (PACU) is standard of care today. It helps to reduce morbidity and even mortality in
high-risk patients.

In addition to clinical monitoring by qualified staff, standard monitoring in the PACU
includes non-invasive, intermittent, haemodynamic monitoring.

This research is going to investigate the influence of the continuation of goal directed
haemodynamic optimization in the recovery room on the basis of non-invasive monitoring
tools, i.e. ultrasound and the volume-clamp method, in regard of length of stay in the
PACU and postoperative complications.

Continuation of Goal Directed Haemodynamic Optimization in the PACU

Hemodynamic Instability

Postoperative Complications

Ultrasound Imaging

Postoperative monitoring of all patients after surgery in post anaesthesia care unit
(PACU) is standard of care today. It helps to reduce morbidity and even mortality in
high-risk patients.

In addition to clinical monitoring by qualified staff, standard monitoring in the PACU
includes non-invasive, intermittent, haemodynamic monitoring. The time of transfer of
patients from the PACU to the general ward is assessed on the basis of several
parameters. There is consensus on the most important endpoints of transferability:
awareness, quality of spontaneous breathing, circulatory situation, bleeding situation,
body temperature, diuresis and satisfactory freedom from pain and absence of nausea, but
the processes and contents and how they can be established as quickly and sustainable as
possible are not yet defined.

This research will investigate the influence of continuing non-invasive, goal-directed
haemodynamic optimization in the recovery room, after major traumatological, general and
vascular surgery.

In a randomized controlled trial the investigators will include a population of 80
patients with a minimum age of 18 years in the study after clarification and approval.

The control group will be routinely treated with an appropriate protocol for
goal-oriented haemodynamic optimization. The study group will receive targeted
haemodynamic optimization using Vigileo FlowTrac-Analysis and transthoracic
echocardiography in the operation room and finger-cuff based pulse analysis technology in
the PACU. The observed parameters of targeted haemodynamic optimization will be stroke
volume and cardiac output, volume response parameters and collapsability of the inferior
vena cava for the volume status.

As primary endpoints the investigators considered the number of postoperative
complications. As secondary endpoints, the investigators will compare the time spent in
the recovery room, the time spent in hospital and 28-day mortality and morbidity.

The hypothesis is that, in patients classified ASA II and III, a continuation of a
targeted haemodynamic optimization in the PACU with non-invasive monitoring methods can
reduce postoperative complications after a variety of surgical procedures.

goal directed intraoperative haemodynamic optimization

Continuation of Goal Directed Haemodynamic Optimization in the Postanaesthesia Care Unit on the Basis of Non-invasive Methods: a Randomized Controlled Trial.

Clinical Professor

Standard of care defined as "standard operating procedure", including a goal directed
intraoperative haemodynamic optimization protocol.

Standard of care defined as "standard operating procedure", including a goal directed
intraoperative haemodynamic optimization protocol. Additional application of a
non-invasive haemodynamic optimization protocol in the post anaesthesia care unit.

Continuation of Goal Directed Haemodynamic Optimization in the PACU

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Not accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status