Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction
Sponsored by University of Virginia
About this trial
Last updated 10 months ago
Study ID
HSR210033
Status
Completed
Type
Interventional
Phase
Phase 4
Placebo
No
Accepting
18+ Years
Female
Not accepting
Healthy Volunteers
Trial Timing
Ended 2 years ago
What is this trial about?
Transversus Abdominis Plane (TAP) block is a useful tool in pain management after
abdominal surgery. It is a regional nerve block that targets T6-L1 thoracolumbar nerves
running in the plane between internal oblique and transversus abdominis muscle. It is
shown to help with post-operative pain management, reducing pain scores and narcotic pain
medication use, as well as promoting earlier return to activity and recovery. TAP block
became a very popular, safe, and effective therapeutic adjunct for many different
abdominal surgeries ranging from obstetric procedures to general surgery procedures like
colorectal surgery. Furthermore, it is used in plastic surgery procedures such as Deep
Inferior Epigastric Perforator (DIEP) free flap or Transverse Rectus Abdominis
Myocutaneous (TRAM) flap, as they involve extensive amount of abdominal soft tissue
incision. Previous studies have shown that TAP block in these procedures significantly
reduce post-op pain and narcotic pain medication use. More recently, Exparel (liposomal
bupivacaine) has risen to spotlight for providing a longer, sustained local anesthesia.
Various surgical disciplines have adopted this agent as part of their pain management
protocol. However, there are no literatures that describe the effect of TAP block using
Exparel for breast free flap population. The study hypothesize that delivering TAP block
with Exparel (vs. plain bupivacaine) will provide longer regional blocking effect, hence
aiding in pain control and recovery postoperatively. The investigators will be analyzing
postop narcotic pain medication requirement and pain scores to look into this question.
What are the participation requirements?
Inclusion Criteria
- All female patients who are 18 years or older who will undergo unilateral or bilateral abdomen-based free flap breast reconstruction at UVA Medical Center
Exclusion Criteria
- Subjects with ages <18 years
- Allergy to local anesthetic
- Inability to tolerate standard postoperative pain management regimen (Tylenol, Toradol, and Oxycodone PRN) for any reason
- Subjects who cannot read or understand English
- Subjects who are pregnant