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Osteoarthritis, Knee

Evaluation of Mangoselect® in Improvement of Exercise/Activity-induced Knee Joint Discomfort in Subjects Suffering From Osteoarthritis Grade I or II

Sponsored by Fytexia

About this trial

Last updated 2 years ago

Study ID

MNGEFS

Status

Completed

Type

Interventional

Phase

N/A

Placebo

Yes

Accepting

18-75 Years
50 to 75 Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 2 years ago

What is this trial about?

The aim of the present investigation is to evaluate the efficacy of Mangoselect®, a mangosteen extract, and of a formulation containing Mangoselect®, in subjects suffering from activity/exercise-induced knee joint pain/discomfort, during a 12-week supplementation period. Subjective discomfort improvement will be assessed with both WOMAC questionnaire and pain Visual Analogic Scale (VAS); functional joints features, quality of life, and inflammatory markers, will also be assessed. Finally, long lasting benefits will additionally be evaluated 4 weeks after the end of the supplementation period. The design of the study is double-blind, randomized, multi-arm, parallel and placebo controlled.

What are the participation requirements?

Yes

Inclusion Criteria

- Physically active volunteers

- BMI 22-29.9 kg/m2

- Declaring knee joint pain during and/or after activity/exercise

- Joint knee pain rated of at least 4 cm on a 10 cm VAS following activity/exercise

- Diagnosed osteoarthritis grade I or II according to Kellgren-Lawrence classification

No

Exclusion Criteria

- Diagnosed inflammatory joint disorder or osteoarthritis grade III or more according to Kellgren-Lawrence classification

- Currentlu chronically taking pain killer drugs or dietary supplement or intra-articular treatment 3 months before selection

- Anemia

- Subjects with knee/joint surgery/replacement in the past 10 years

- Significant injury of the studied knee joint 12 months before selection

- Unable to carry out functional tests and/or questionnaires

- Currently participating or having participated in another clinical trial in the 3 previous months

- Pregnant women and women positive at Beta-HCG serology test

- Any condition that the investigator believes would interfere with the ability to provide inform consent, or comply with study instructions, or confound the interpretations of the study results, or put the volunteer at undue risk

- Allergy to one of the component of the supplements

Locations

Location

Status