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Multiple Sclerosis

Cognitive Improvement Through tDCS for Patients With Multiple Sclerosis

Sponsored by University Medicine Greifswald

About this trial

Last updated 2 years ago

Study ID

MS-CICS

Status

Active, not recruiting

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 2 years ago

What is this trial about?

Multiple sclerosis (MS) is a chronic inflammatory disease with around 200.000 patients in Germany. Besides physical symptoms, cognitive resources degrade over the years. Transcranial direct current stimulation (tDCS) is an established procedure to modulate cortical excitability in motor and cognitive functions. Therefore, tDCS may improve cognitive functions in patients with MS. Patients will work on a modified version of the symbol digits modalities test in two experimental sessions. During the task, they will receive either active stimulation or sham stimulation in a crossover design. Active stimulation is divided in anodal and cathodal stimulation. Anodal stimulation should facilitate cognitive processing; cathodal stimulation, on the other hand, should hinder cognitive processing.

What are the participation requirements?

Yes

Inclusion Criteria

- diagnosis of multiple sclerosis.

- no acute inflammation during the last 3 months before the experimental intervention.

- no cortisol treatment during the last 3 months before the experimental intervention.

- stable medication during the experimental intervention.

- unrestrained or corrected visual ability.

- ability to read and write short german sentences.

- adequate motor ability to give responses on a keyboard.

- German as main language.

No

Exclusion Criteria

- major depressive symptoms or any further neurological and/or psychiatric disease at experimental intervention.

- standard tDCS exclusion criteria (e.g. cardiac pacemaker, metal implants in head region, etc.)

Locations

Location

Status