Exploring the Immunology of Sarcoidosis
Sponsored by Hull University Teaching Hospitals NHS Trust
About this trial
Last updated 2 years ago
Study ID
R2421
Status
Recruiting
Type
Observational
Placebo
No
Accepting
18 to 85 Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended a year ago
What is this trial about?
In sarcoidosis, over activity of parts of the immune system drives the accumulation of
granulomas (collections of immune cells) in affected parts of the body. To facilitate
development of effective and safe treatment options in the future it will be vital to
understand how and why the immune system becomes over active. The aim of this research is to
work towards this goal by studying cells of the immune system and the molecular pathways
inside these cells that control how they behave. This will be achieved by analysing patterns
of proteins and RNA (the code used to tell cells which proteins to produce) in immune cells
present in blood samples and tissue biopsies from people with sarcoidosis.
What are the participation requirements?
Inclusion Criteria
1. Males or females, of any race, between 18 and 85 years of age, inclusive
2. Able to provide written informed consent
3. Clinician diagnosis of sarcoidosis
4. Treatment-naïve or receiving immunomodulatory therapy.
Exclusion Criteria
1. Evidence of acute bacterial infection or other condition likely in the opinion of the investigator to significantly impact results of blood assays.
Locations
Location
Status
Recruiting