Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases
Sponsored by Hospital Universitario La Fe
About this trial
Last updated 2 years ago
Study ID
Status
Type
Placebo
Accepting
Trial Timing
Started 4 years ago
What is this trial about?
What are the participation requirements?
Inclusion Criteria
- ≥ 18 and ≤ years
- Good performance status, ECOG 0 or 1
- Resected adenocarcinoma in colon or rectum (R0 resection)
- Unresectable liver metastases
- No extrahepatic disease
- Normal blood tests
- Response to ≤ 2 lines of chemotherapy (RECIST criteria)
- ≥ 1 year period since diagnosis of colorectal cancer to enrolment in liver transplant waiting list
- Signed informed consent
Exclusion Criteria
- Body mass index ≥ 30
- Positive HIV or HCV
- Pregnancy at the time of inclusion
- BRAF mutated status
- Deterioration of general condition (10% weight loss in the prior 6 months)
- Other malignancy with disease free survival < 5 years
- Concomitant or prior extrahepatic metastases (histologically or radiologically proved), even if surgically resected.
- Palliative resection of primary colorectal adenocarcinoma
- Liver metastases size > 5 cm (in the last imaging technique)
- CEA > 80 ng/ml (at time of enrolment in waiting list)
- No neoadjuvant chemotherapy treatment
- General contraindication to liver transplantation