To quantify the seroprevalence of antibodies to AAV5, AAV6, and AAV8 and the seroconversion
      rate over varying follow-up intervals in subjects with hemophilia A

A Study to Evaluate Seroprevalence and Seroconversion of Antibodies to Adeno-Associated Virus (AAV) in Patients With Hemophilia A

Hemophilia A

This is a single-center, decentralized, patient-centered, prospective, observational study
      utilizing biospecimen samples collected from hemophilia A subjects across the United States
      to evaluate and characterize seroprevalence and the rate of seroconversion of antibodies
      against AAV serotypes and exploratory vectors, and to investigate the associated factors that
      may influence the vector titers.

      Relevant medical findings will also be collected from the subject, as well as symptoms
      related to hemophilia A. The collection of medical history may include major illnesses,
      diagnoses, and surgeries.

Blood sample collection

A Prospective, Observational Study Evaluating Seroprevalence and Rate of Seroconversion of Antibodies Against Adeno-associated Virus (AAV) Serotypes and Exploratory Vectors in Subjects With Hemophilia A in the United States

To assess the Seroprevalence of antibodies to AAV vectors in patients with hemophilia A at Baseline

To describe and characterize AAV vector titer values in subjects with Hemophilia A

A Study to Evaluate Seroprevalence and Seroconversion of Antibodies to Adeno-Associated Virus (AAV) in Patients With Hemophilia A

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status