Purpose of the study:

The purpose of the study is to evaluate the therapeutic effect of cryotherpy in treating
hypertrophic scar.

It will be hypothesized that:

Cryotherapy may not have an effect on hypertrophic scar.

Effect of Cryotherpy on Hypertrophic Scar

Hypertrophic Scars

The potential of cryotherapy application in vitro data indicated that using freezing
treatment on VFFs + TGF-β1 (myofibroblast) modulated ECM turnover toward antifibrosis and
normalization, attenuated myofibroblast differentiation, reduced cell migration, and
weakened the contractile activity. On both VFFs ± TGF-β1, freezing treatment raised LP
regeneration (HAS1, decorin).

The findings indicate that cryotherapy may play a protective role in scar formation and
contribute to lamina regeneration.

Furthermore the need of this study was developed from the lack in the quantitative
knowledge and information in the published studies about the effect of cryotherapy on
hypertrophic scar.

This study will be designed to provide a guideline about the effect of effect of
cryotherapy on hypertrophic scar height, thickness and discoloration, and to assist in
planning an ideal treatment regimen for reducing hypertrophic scar.

Delimitations:

This study will be delimited in the following aspects:

  1. Subjects:

     Sixty patients suffering from hypertrophic scar will be randomly divided into two
     equal groups each one has 30 patients.

  2. Equipment and tools:

2.1. Measurement equipment: Vancouver scar scale. MAPS (Matching Assessment of Scars and
Photographs). 2.2. Therapeutic equipment: Gymna Cryoflow ICE-CT. Temperature resistant
polymide tape (48 wide).

Hypothesis:

It will be hypothesized that:

Cryotherapy may not have an effect on hypertrophic scar.

Basic Assumptions:

It will be assumed that:

  -  All patients will receive the same kinds of medication and the same nursing care.

  -  All subjects are free from any chronic disease.

  -  All subjects will continue in the study.

  -  All patients will follow the instructions during the treatment

cryotherapy (Gymna Cryoflow ICE-CT)

Exercising, Positioning and splinting, Pressure Therapy and Massage

The potential of cryotherapy application in vitro data indicated that using freezing
treatment on scar decrease its height

Professor of Physical Therapy for Surgery Faculty of Physical Therapy

This group includes 30 patients will receive routine medical treatment and routine
physical therapy as (Exercising, Positioning and splinting, Pressure Therapy and
Massage).

This group includes 30 patients will receive cryotherapy (at least 10 minutes at -14
degree , 2 sessions per week , for 10 weeks ) in addition to routine medical and physical
therapy treatment.

Effect of Cryotherpy on Hypertrophic Scar

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Not accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status