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Study to Investigate the Efficacy and Pharmacokinetic Profile of K-877-ER Compared to K-877-IR

Sponsored by Kowa Research Institute, Inc.

About this trial

Last updated 4 years ago

Study ID

K-877-ER-201

Status

Completed

Type

Interventional

Phase

Phase 2

Placebo

No

Accepting

18-75 Years
18+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 5 years ago

What is this trial about?

A study to evaluate the efficacy of K-877 extended release (ER) once daily (QD) compared to K-877 immediate release (IR) twice daily (BID).

What are the participation requirements?

Yes

Inclusion Criteria

- Able to provide written informed consent before any study-specific evaluation is performed

- At screening, have a mean fasting TG level of ≥180 mg/dL and <550 mg/dL; at subsequent Qualification Period visits confirm fasting TG level of ≥200 mg/dL and <500 mg/dL

- Able to meet all inclusion criteria outlined in clinical study protocol

No

Exclusion Criteria

- Require lipid-altering treatments other than study drugs, statins, ezetimibe, or PCSK9 inhibitors during the study

- Known hypersensitivity or intolerance to fibrates or peroxisome proliferator-activated receptor alpha agonists

- Meet any other exclusion criteria outlined in clinical study protocol

Locations

Location

Status