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Mediterranean Diet Treatment for NAFLD

Sponsored by Antalya Training and Research Hospital

About this trial

Last updated 6 years ago

Study ID

2017-234

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

9 to 17 Years
All Sexes

Trial Timing

Ended 6 years ago

What is this trial about?

Treatment for Nonalcoholic Fatty Liver Disease (NAFLD) is through lifestyle modification consisting of caloric restriction and exercise, with an emphasis on weight loss. Unfortunately, the success and longevity of lifestyle changes that focus on weight loss, are poor in children. The dietary recommendation of calorie restriction alone may not be optimal in a pediatric population for multiple reasons including changes in hormonal milieu, growth velocity, and decreased bone mineral density that occur with significant weight loss. Mediterranean Diet (MD) is based on the high intake of extra virgin olive oil, vegetables, fruits, cereals, nuts and legumes; moderate intakes of fish and other meats, dairy products and red wine and low intakes of eggs and sweets. So, it provides a large amount of monounsaturated fatty acids, polyunsaturated fatty acids, vegetable proteins, fibre and antioxidants; and low amounts of sugar, cholesterol and saturated fats. It offers a lot of choice in food selection, and well tolerated, and many people can adhere to it over the long term. The investigators aimed to evaluate the effects of a MD vs. low fat diet on changes in hepatic steatosis, aminotransferases, and anthropometric measurements among obese children with NAFLD

What are the participation requirements?

Inclusion Criteria

* Diagnosis of NAFLD

* Body mass index z-score >85th percentile

Exclusion Criteria

* Secondary causes of NAFLD (eg. medication induced)

* Use of weight loss medications

* Diabetes Mellitus

* Other causes of fatty liver disease (eg. Wilson disease, alpha-1 antitrypsin deficiency, auto-immune hepatitis, and viral hepatitis)