Pineapple (Ananas comosus) is a tropical fruit that is rich in antioxidents, enzymes and
      vitamins. It is used worldwide due to their anti-inflammatory and analgesic properties. The
      effect of pineapple Juice on the Pharmacokinetics of celecoxib and montelukast in Humans was
      studied.

Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans

Food-drug Interaction

Celecoxib 100mg

Montelukast 10mg

Associate professor

Twelve healthy male subjects participated in this arm under fasting condition. A randomized, open-label, 2-way crossover study design with 2-week washout period between treatments was used. Participants received a single oral dose of celecoxib tablets (100mg) after pre-treatment with 250ml of either pineapple juice or water (control) for four consecutive days before the beginning of the study.

Twelve healthy male subjects participated in this arm under fasting condition. A randomized, open-label, 2-way crossover study design with 2-week washout period between treatments was used. Participants received a single oral dose of Montelukast tablets (10mg) after pre-treatment with 250ml of either pineapple juice or water (control) for four consecutive days before the beginning of the study.

Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status