Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery
Sponsored by South Egypt Cancer Institute
About this trial
Last updated 5 years ago
Study ID
Assuit University
Status
Completed
Type
Interventional
Phase
Phase 2/Phase 3
Placebo
No
Accepting
21 to 60 Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended 5 years ago
What is this trial about?
The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory
drugs (NSAID) such as celecoxib were used as a part of multimodal analgesia to control
such pain. Gabapentin is an anticonvulsant drug that has analgesic effect in
post-herpetic neuralgia, diabetic neuropathy, and neuropathic pain. Celecoxib is one of
the NSAIDs, that its analgesic effect is reported in various studies by cyclooxygenase-2
(COX-2) inhibitor.
The aim of this randomized double-blinded study was to asses and compare the efficacy of
using gabapentin versus celecoxib as a part of multimodal analgesia in perioperative
hemodynamic control and pain relief in patients underwent posterior approach lumbar spine
disc fixation surgery.
What are the participation requirements?
Inclusion Criteria
- American society of anesthesiologists (ASA) I and II, aged between 21-60 years old scheduled to undergo elective posterior approach lumbar spine disc surgery
Exclusion Criteria
- Patients with a known sensitivity to celecoxib or pregabalin, psychotic disorder or cognitive impairment, history of drug dependency or substance addiction, history of chronic medical disease, the presence of coagulation disorders or pregnancy, were excluded from the study.