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Identification of Biomarkers in Ischemic Stroke - Clinical Trial

Sponsored by University Hospital, Brest

About this trial

Last updated 2 years ago

Study ID

IBIS-CT (29BRC19.0268)

Status

Recruiting

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18 to 99 Years
All
All

Trial Timing

Ended a year ago

What is this trial about?

The objective of the study is to determine RNA blood biomarker based on 9 genes already identified in experimental studies, whose expression would be significantly increased in patient with ischemic stroke compared to controls.

What are the participation requirements?

Yes

Inclusion Criteria

- For ischemic stroke :

- Age > 18-year-old

- Ischemic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRI imaging)

- Inclusion inferior to 6 hours from stroke onset

- Initial NIHSS score > 0 at the time of clinical examination

- Patients with multimodal imaging either through MRI or CT perfusion and supra-aortic vessels and intra-cerebral vessels (Willis circle) imaging <0

- Procedure of signed consent in situation of emergency : consent of the patient if he has the possibility to sign or his representative if he is present

- For hemorragic stroke :

- Age > 18 year-old

- Hemorrhagic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRI imaging)

- Inclusion inferior to 6 hours from stroke onset

- Initial NIHSS score > 0 at the time of clinical examination

- Hemorrhagic patients are paired for age and sex with ischemic patients

- Procedure of signed consent in situation of emergency : consent of the patient if he has the possibility to sign or his representative if he is present For healthy controls :

- Age > 18 year-old

- Stroke-free standardized questionnaire

- Initial NIHSS score = 0

- Rankin score = 0

- High risk cardiovascular subjects

- Controls are paired for age, sex and cardiovascular risk measured by a score (European Heart Score) with ischemic patients

No

Exclusion Criteria

- Not affiliated to social security

- Patient under legal protection or deprived of liberty by a judicial or administrative decision

- Patient whose follow-up will be impossible

- Prior stroke GROUP FOR ISCHEMIC STROKE :

- Patients with TIA and a negative cerebral CT or MRI GROUP FOR HEMORRAGIC STROKE :

- Cerebral hemorrhage related to subarachnoid hemorrhage
- Post-traumatic hemorrhage
- Hemorrhagic transformation in patients with ischemic stroke GROUP FOR HEALTHY CONTROLS :

- Contraindication MRI

Locations

Location

Status

Recruiting