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Chronic Kidney Diseases

Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease

Sponsored by University Hospitals of Derby and Burton NHS Foundation Trust

About this trial

Last updated 2 years ago

Study ID

DHRD/2018/100

Status

Recruiting

Type

Observational

Placebo

No

Accepting

18-75 Years
18 to 75 Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Started 4 years ago

What is this trial about?

Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: 1. To establish a multiparametric renal MRI protocol in CKD cohorts. 2. To use multiparametric MRI to characterise people with and without CKD progression. 3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.

What are the participation requirements?

Yes

Inclusion Criteria

- Age 18-75 years

- CKD category G3-4 or CKD category G1-2 with overt albuminuria (urine ACR>30mg/mmol)

- Capable of giving informed consent

No

Exclusion Criteria

- Autosomal dominant polycystic kidney disease (ADPKD)

- Glomerulonephritis (GN) actively receiving immunosuppression, or within the preceding 90 days.

- Multiple myeloma (MM)

- Acute Kidney Injury (AKI) within the preceding 90 days

- Solid organ transplant

- Known single kidney

- Contraindications to MRI (e.g. permanent pacemaker, metallic foreign bodies, claustrophobia etc.)

Locations

Location

Status

Recruiting