Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke

- 1) Age≥18 years, < 80 years, regardless of sex;

- 2) Patients with clinically definite diagnosis of acute ischemic stroke and undergo intravenous thrombolysis;

- 3) Baseline NIHSS >= 5, and <= 25;

- 4) Baseline GCS ≥8;

- 5) Signed and dated informed consent is obtained

- 1) Patients who undergo endovascular treatment;

- 2) mRS ≥ 2 before the onset of the disease;

- 3) Double upper limbs or lower limbs paralysis was found in this case;

- 4) Active bleeding of organs within 6 months of admission or current, including cerebral hemorrhage, subarachnoid hemorrhage, gastrointestinal hemorrhage, fundus hemorrhage and so on;

- 5) Other intracranial lesions, such as cerebrovascular malformation cerebral venous diseases, tumor and other diseases involving the brain;

- 6) Concurrent use of anticoagulation drugs including Warfarin, dabigatran, rivaroxaban;

- 7) Severe organ dysfunction or failure;

- 8) Patients suffering from severe hematological diseases or severe coagulation disorder dysfunction

- 9) Those who have a history of severe trauma or had major surgery within 6 months prior to admission;

- 10) Those who have a history of atrial fibrillation;

- 11) The patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb#Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc;

- 12) Pregnant or lactating women;

- 13) Previous remote ischemic conditioning therapy or similar treatment;

- 14) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons;

- 15) Severe hepatic and renal dysfunction;

- 16) Unwilling to be followed up or treated for poor compliance;

- 17) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission;

- 18) Other conditions that the researchers think are not suitable for the group.