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ASC-US
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Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?

Sponsored by Sanliurfa Mehmet Akif Inan Education and Research Hospital

About this trial

Last updated 6 years ago

Study ID

714

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
30 to 65 Years
Female
Female

Trial Timing

Ended 10 years ago

What is this trial about?

Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis. Mostly human papillomavirus (HPV) is responsible for this transition. Most of them are transient, but some infections become persistent and can progress into precancer and invasive cancer. In the process of progression to cancer; patients with cell cycle problems are thought to be at risk. In some studies, B12 and folate deficiency, which play a role in DNA synthesis and repair, have been shown to induce incorrect binding of uracil to DNA, leading to DNA breakage and repair disorder. Therefore, in this study, it has been aimed that the relation of presence of atypical squamous cells and HPV persistence with folate and vitamin B12 levels which effect on immune system.

What are the participation requirements?

Yes

Inclusion Criteria

- female patients aged between 30-65 who were undergoing smear tests with the aim of control

- body mass index (BMI) lower than 35

- Participants did not have any chronic diseases

No

Exclusion Criteria

- Patients taking B12 and folate supplement due to mix type anemia

- patients taking active vitamin B12 and folate-containing vitamin supplements

- pregnant women

- women with other cervical intraepithelial lesions such as low grade squamous intraepithelial lesion (LGSIL), high grade squamous intraepithelial lesion (HGSIL) or high grade squamous intraepithelial lesion can not be excluded (ASC-H) in smear

- patients with cervical cancer diagnosis

- patients who were operated due to cervical cancer

- patients who had HPV vaccine

- patients with a diagnosis that can inhibit B12 and folate absorption in gastro-intestinal tract

- vegetarians