The effect of N-acetylcysteine supplementation on carbohydrate metabolism disorder and
      homocysteine concentrations in obese women will be analysed.

N-acetyl-cysteine and Carbohydrate Metabolism Disorder in Obese Women

Insulin Resistance

Obesity

Carbohydrate Metabolism Disorder

NAC group

Control group

Does N-acetyl-cysteine Treatment Improves Carbohydrate Metabolism in Obese Women?

Fasting insulin concentration (uU/ml) will be measured before and after 2 hours of 75g glucose drink. Insulin resistance will be measured before and after 12 weeks of the intervention.

Fasting glucose concentration (mg/dL) will be measured before and after 2 hours of 75g glucose drink. OGTT test will be measured before and after 12 weeks of the intervention. Fasting glucose and fasting insulin concentrations will be combined to report HOMA-IR index (homeostatic model assessment of insulin resistance).

dr hab, Director of Institute of Human Nutrition and Dietetics

Plasma homocysteine concentrations at baseline and after 12 weeks of the intervention

Plasma glutathione concentrations will be measured at baseline and after 12 weeks of the intervention

Body weight will be assemsment at baseline and after 4,8 and12 weeks of the intervention. Weight and height will be combined to report BMI in kg/m^2.

Body height will be assemsment at baseline of the intervention.

BMI (body mass index kg/m2) will be assemsment at baseline and after 4, 8 and 12 weeks of the intervention.

Fat mass (%) and Fat free mass (%) will be assement at baseline and after 4, 8 and 12 weeks of the intervention.

Methylenetetrahydrofolate reductaseMTHFR polymorphism will be measured only at baseline (before intervention).

Blood lipid profile: cholesterol mg/dL, low-density lipoprotein LDL mg/dL, high-density lipoprotein HDL mg/dL, triglycerides mg/dL will be measured at baseline and after 12 weeks of the intervention.

Cytokine: IL-6 pg/ml, IL- 10 pg/ml, TNF - α pg/ml will be measured at baseline and after 12 weeks of the intervention.

C-Reactive Protein will be measured at baseline and after 12 weeks of the intervention

NAC for 12 weeks, 1.6 mg/day, 4x400 mg; a diet based on general recommendations for people with carbohydrate metabolism disorder

Placebo for 12 weeks and a diet based on general recommendations for people with carbohydrate metabolism disorder

N-acetyl-cysteine and Carbohydrate Metabolism Disorder in Obese Women

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Not accepting

Trial Timing

What is this trial about?

What are the participation requirements?