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The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women

Sponsored by Cairo University

About this trial

Last updated 6 years ago

Study ID

50

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18 to 45 Years
Female

Trial Timing

Ended 6 years ago

What is this trial about?

A full medical history will be obtained from all participants. Obstetric ultrasonography and laboratory tests will be performed.According to group assignment, either 1 g(10 mL) tranexamic acid stored in a dry container at 15 °C-30 °C) diluted in 20 mL of 5% glucose or 30 mL of 5% glucose will be slowly administered intravenously 15 minutes before skin incision over a 5-minute period. Following delivery, patients in both groups will receive an intravenous bolus of 5 IU oxytocin , 1 mL(0.2 mg) intramuscular ergometrine , and 20 IU oxytocin in 500 mL lactated Ringer's solution(infused at a rate of 125 mL/h)

What are the participation requirements?

Inclusion Criteria

* • Grand multipara

* Multiple pregnancy
* Polyhydraminos (AFI is more than 24 cm).
* Placenta previa
* Gestational diabetes mellitus
* Preeclampsia
* Anemia complicating pregnancy (Hemoglobin is less than 11 gm/dl)

Exclusion Criteria

* • Allergy to tranxemic acid.

* H/o suggestive of bleeding disorders
* previous history of deep vein thrombosis
* Abnormally invasive placenta
* Emergency cesarean sections
* Intraoprative complications during cesarean sections as uterine artery injury and broad ligamentary hematoma.