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PAVmed CarpX Device Clinical Study

Sponsored by PAVmed Inc.

About this trial

Last updated 5 years ago

Study ID

PAVmed CarpX-01-018

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 5 years ago

What is this trial about?

To study the safety and feasibility of the CarpX device to divide and release the transverse carpal ligament in order to provide relief for Carpal Tunnel Syndrome (CTS).

What are the participation requirements?

Yes

Inclusion Criteria

- Patient is > 18 years old

- Patient is scheduled to undergo carpal tunnel release surgery

- Patient has failed to respond to conservative treatment of CTS

- CTS confirmed by strong clinical signs and positive Nerve Conduction Velocity (NCV) test

- Patient, or authorized representative, signs a written Informed Consent form to participate in the study, prior to any study mandated procedures Patient is willing and able to complete follow-up requirements

No

Exclusion Criteria

- Patient has a prior or current musculoskeletal or neurologic condition that limits strength, motion, or sensation in the affected hand that is unrelated to carpal tunnel syndrome.

- Patient with stiff wrist, suspected space occupying lesions or other anatomic abnormalities of the forearm, wrist or hand or other concerns related to patient anatomy such as small wrist and/or thin skin

- Prior invasive treatment of the hand or wrist for disease processes such as De Quervain's syndrome, arthritic wrist etc. on the intended treatment side

- Previous trauma/fracture or other anatomic abnormalities of the forearm, wrist or hand on the intended treatment side

- Patient has an ipsilateral injury or other conditions affecting hand function

- Patient has acute CTS resulting from an injury (e.g., fracture)

- Patient has had previous CTR surgery on the affected hand

- Patient has severe chronic median nerve neuropathy shown by the EMG and NCS that shows denervation of the thenar muscle

- Active local or systemic infection

- Known allergy to any device component

- Known severe allergy to contrast reagent that cannot be managed with premedication

- Any significant medical condition(s) that would place patient at excessive risk for surgery such as: known bleeding disorder including thrombocytopenia (platelet count < 80,000), thrombasthenia, hemophilia or Von Willebrand's disease, unstable cardiac disease, renal failure or uncontrolled diabetes

- Patient has other medical, social or psychological problem that in the opinion of the investigator precludes them from fully participating

- Women who are pregnant

Locations

Location

Status