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Evaluate the Safety, Tolerability, & Pharmacokinetics of K-285 Compared With Indomethacin Capsule in Healthy Adults

Sponsored by Kowa Research Institute, Inc.

About this trial

Last updated 7 years ago

Study ID

K-285-101

Status

Completed

Type

Interventional

Phase

Phase 1

Placebo

No

Accepting

18-75 Years
18 to 45 Years
All
All

Trial Timing

Ended 7 years ago

What is this trial about?

This study is to compare the PK parameters of multiple doses and applications of K-285 with a single dose of indomethacin capsule.

What are the participation requirements?

Yes

Inclusion Criteria

- Subject provides written informed consent before any study specific evaluation is performed.

- Subject is a healthy adult male or female aged 18 to 45 years, inclusive.

- Subject has a BMI of 18 to 30 kg/m2, inclusive.

- Subject meets all inclusion criteria outlined in the clinical study protocol.

No

Exclusion Criteria

- Subject has abnormal findings or assessments that are clinically noteworthy at Screening or Admission (Day -1).

- Subject has a supine blood pressure after resting for 5 minutes that is higher than 140 mm Hg systolic or 90 mm Hg diastolic, or lower than 90 mm Hg systolic or 50 mm Hg diastolic at Screening or Admission (Day -1).

- Subject has a supine heart rate after resting for 5 minutes that is outside the range of 40 to 100 beats per minute at Screening or Admission (Day -1).

- Subject does not meet any exclusion criteria outlined in the clinical study protocol.

Locations

Location

Status